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Selected Publications

RASA2 ablation in T cells boosts antigen sensitivity and long-term function
Nature, 2022
CRISPR activation and interference screens decode stimulation responses in primary human T cells
Science, 2022
Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies
Cell, 2020
Functional CRISPR dissection of gene networks controlling human regulatory T cell identity
Nature Immunology, 2020
CRISPR screen in regulatory T cells reveals modulators of Foxp3
Nature, 2020
Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function
Cell, 2018

News

Media highlights of Alex and the lab’s research.
How Unique Immune Cells Can Recognize—and Destroy—Tumors
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Giving Immunotherapy Cells Resilience to Pass the ‘Stress Test’
Read More >>
Gene Editing Expands to New Types of Immune Cells
Read More >>
Genetic Network that Differentiates Regulatory T Cells Mapped
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Scientists map genes controlling immune system “brakes”
Read More >>