Publications

Links to all papers from the lab are organized by year of publication.

  • Advancing T cell–based cancer therapy with single-cell technologies, Nature Medicine
  • High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails, Nature Biotechnology
  • RASA2 ablation in T cells boosts antigen sensitivity and long-term function, Nature
  • Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks, Nature Genetics
  • Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling, Cell Reports
  • Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression, Molecular & Cellular Proteomics
  • Obesity alters pathology and treatment response in inflammatory disease, Nature
  • A functional map of HIV-host interactions in primary human T cells, Nature Communications
  • CRISPR activation and interference screens decode stimulation responses in primary human T cells, Science
  • CRISPR–Cas9-mediated nuclear transport and genomic integration of nanostructured genes in human primary cells, Nucleic Acids Research
  • Efficient Generation of Isogenic Primary Human Myeloid Cells using CRISPR-Cas9 Ribonucleoproteins, Cell Reports
  • XYZeq: Spatially resolved single-cell RNA sequencing reveals expression heterogeneity in the tumor microenvironment, Science Advances
  • Pooled screening of CAR T cells identifies non-native signaling domains for next-generation immunotherapies, bioRxiv
  • Hybrid ssDNA repair templates enable high yield genome engineering in primary cells for disease modeling and cell therapy manufacturing, bioRxiv
  • Evaluation of SARS-CoV-2 serology assays reveals a range of test performance, Nature Biotechnology
  • Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies, Cell
  • Functional CRISPR dissection of gene networks controlling human regulatory T cell identity, Nature Immunology
  • CRISPR screen in regulatory T cells reveals modulators of Foxp3, Nature
  • Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency, Nature Biotechnology
  • Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR), EMBO J
  • Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair, Nature Communications
  • T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk, bioRxiv
  • Landscape of stimulation-responsive chromatin across diverse human immune cells, Nature Genetics
  • Orthotopic replacement of T-cell receptor alpha and beta chains with preservation of near-physiological T-cell function, Nature Biomedical Engineering
  • CRISPR-Based Tools in Immunity, Annual Review of Immunology
  • Helios enhances the preferential differentiation of human fetal CD4+ naive T cells into regulatory T cells, Science Immunology
  • A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells, Immunity
  • Large dataset enables prediction of repair after CRISPR-Cas9 editing in primary T cells, Nature Biotechnology
  • A large CRISPR-induced bystander mutation causes immune dysregulation, Communications Biology
  • CRISPR-Cas9 genome engineering of primary CD4 + T cells for the interrogation of HIV-host factor interactions, Nature Protocols
  • Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function, Cell, 2018 | Learn More
  • Reprogramming human T cell function and specificity with non-viral genome targeting, Nature, 2018 | Learn More
  • CRISPR-Cas9 genome engineering of primary CD4 + T cells for the interrogation of HIV-host factor interactions, Nature Protocols, 2018 | Learn More
  • Multiplexed droplet single-cell RNA-sequencing using natural genetic variation, Nature Biotechnology, 2018 | Learn More
  • Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins, Journal of Immunological Methods, 2018 | Learn More
  • Discovery of stimulation-responsive immune enhancers with CRISPR activation, Nature, 2017 | Learn More
  • A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors, Nature Genetics, 2017 | Learn More
  • CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells, Scientific Reports, 2017 | Learn More
  • Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements, Nature Genetics, 2017 | Learn More
  • “T-bet”-ing on autoimmunity variants, PLOS Genetics, 2017 | Learn More

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells, Cell Reports, 2016 | Learn More

  • Genetic and epigenetic fine mapping of causal autoimmune disease variants, Nature, 2015 | Learn More
  • The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation, Immunity, 2015 | Learn More
  • Generation of knock-in primary human T cells using Cas9 ribonucleoproteins, PNAS, 2015 | Learn More
  • Genetic basis of autoimmunity, The Journal of Clinical Investigation, 2015 | Learn More
  • Small-molecule ROR-gamma-t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms, Immunity, 2014 | Learn More
  • Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells, Cell, 2008 | Learn More
  • Wnt signaling promotes reprogramming of somatic cells to pluripotency, Cell Stem Cell, 2008 | Learn More
  • Foxp3 occupancy and regulation of key target genes during T-cell stimulation, Nature, 2007 | Learn More

Featured In

News

Media highlights of Alex and the lab’s research.
A Cellular Engineering Breakthrough: High-Yield CRISPR Without Viral Vectors
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A gene not previously known to regulate immunity could turn tired T-cells around
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Giving Immunotherapy Cells Resilience to Pass the ‘Stress Test’
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CRISPR and HIV: New technique in human blood unveils potential paths toward cure
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How Obesity Can Rewire the Immune System and the Response to Immunotherapy—and How to Change That
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Obesity can turn a helpful immunotherapy into a harmful one, mouse study shows
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Living Therapeutics Initiative Will Accelerate Development and Delivery of Revolutionary Treatments
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Gene Editing Expands to New Types of Immune Cells
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Gladstone Scientist Uses YouTube to Fight COVID-19 Misinformation in India
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How CRISPR Tools are Unlocking New Ways to Fight Disease
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Crispr: Breakthrough announced in technique of 'editing' DNA to fight off deadly illnesses
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CRISPR-Based “Discovery Engine” for New Cell Therapies to Advance Cancer Treatments
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With new genes and an electric shock, scientists turn immune cells against cancer
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Swift Gene-Editing Method May Revolutionize Treatments for Cancer and Infectious Diseases
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First Human Trial of Engineered T cells
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In autoimmune diseases affecting millions, researchers pinpoint genetic risks, cellular culprits
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Blunting CRISPR’s “scissors” gives new insight into autoimmune disorders
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"Gentler” CRISPR sheds light on autoimmune disease
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Engineering the Next Generation of Cell Therapies
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Once Science Fiction, Gene Editing is Now a Looming Reality
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Genetic Network that Differentiates Regulatory T Cells Mapped
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Scientists map genes controlling immune system “brakes”
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CRISPR identifies genes that might be targeted to hobble HIV infection
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Antibody Test, Seen as Key to Reopening Country, Does Not Yet Deliver
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Stellar Science Solving Cancer and COVID-19
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Meet Dr. Alexander Marson, One of CRI’s New Lloyd J. Old STARs
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The Immuno-Revolution: Resolving “Complexity Exemplified”
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Gladstone launches 2 new institutes — one focused on Covid-19, the other on cell therapies
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Two New Research Institutes in the Bay Area
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Why DNA is the Most Exciting Programming Language Today
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Coronavirus Antibody Tests: Can You Trust the Results?
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Interviews

Recent videos and interviews with Alex.
Bio Eats World: Discovery, Translation, and the State of Bio Today
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Alex appears on 60 minutes to discuss COVID-19 antibody testing
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Alex discusses the COVID testing project on CNN
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Science is Fun Podcast
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American Society of Gene & Cell Therapy (ASGCT) Meeting
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Stay Updated

Keep up-to-date with the latest research from the Marson lab.

“T-cells are a central cell type that we can engage in a number of different ways to start ...orchestrating responses to treat cancer.” — @MarsonLab https://arkinv.st/3T1F4ao

Looking forward to this for a number of reasons, including the opportunity to catch up with my PhD ...Mentor @youngricka. Should be a great meeting!

Now Live! – “From Bench to Fireside,” a conversation between John Connolly, PhD, and Alex ...Marson, MD, PhD, @MarsonLab at Gladstone-@UCSF Institute of Genomic Immunology, and, now, director of PICI @GladstoneInst. https://youtu.be/VA7bKIQ7cA4 #PICINetwork

Schedule An Interview

Contact Jackie Sawin to schedule an interview with Alex Marson.