Publications

Links to all papers from the lab are organized by year of publication.

  • Efficient Generation of Isogenic Primary Human Myeloid Cells using CRISPR-Cas9 Ribonucleoproteins, Cell Reports
  • XYZeq: Spatially resolved single-cell RNA sequencing reveals expression heterogeneity in the tumor microenvironment, Science Advances
  • CRISPR activation and interference screens in primary human T cells decode cytokine regulation, bioRxiv
  • Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks, bioRxiv
  • Pooled screening of CAR T cells identifies non-native signaling domains for next-generation immunotherapies, bioRxiv
  • Hybrid ssDNA repair templates enable high yield genome engineering in primary cells for disease modeling and cell therapy manufacturing, bioRxiv
  • Evaluation of SARS-CoV-2 serology assays reveals a range of test performance, Nature Biotechnology
  • Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies, Cell
  • Functional CRISPR dissection of gene networks controlling human regulatory T cell identity, Nature Immunology
  • CRISPR screen in regulatory T cells reveals modulators of Foxp3, Nature
  • Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency, Nature Biotechnology
  • Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR), EMBO J
  • Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair, Nature Communications
  • T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk, bioRxiv
  • Landscape of stimulation-responsive chromatin across diverse human immune cells, Nature Genetics, 2019 | Learn More
  • Orthotopic replacement of T-cell receptor alpha and beta chains with preservation of near-physiological T-cell function, Nature Biomedical Engineering, 2019 | Learn More
  • CRISPR-Based Tools in Immunity, Annual Review of Immunology, 2019 | Learn More
  • Helios enhances the preferential differentiation of human fetal CD4+ naive T cells into regulatory T cells, Science Immunology, 2019 | Learn More
  • A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells, Immunity, 2019 | Learn More
  • Large dataset enables prediction of repair after CRISPR-Cas9 editing in primary T cells, Nature Biotechnology, 2019 | Learn More
  • A large CRISPR-induced bystander mutation causes immune dysregulation, Communications Biology, 2019 | Learn More
  • CRISPR-Cas9 genome engineering of primary CD4 + T cells for the interrogation of HIV-host factor interactions, Nature Protocols, 2019 | Learn More
  • Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function, Cell, 2018 | Learn More
  • Reprogramming human T cell function and specificity with non-viral genome targeting, Nature, 2018 | Learn More
  • CRISPR-Cas9 genome engineering of primary CD4 + T cells for the interrogation of HIV-host factor interactions, Nature Protocols, 2018 | Learn More
  • Multiplexed droplet single-cell RNA-sequencing using natural genetic variation, Nature Biotechnology, 2018 | Learn More
  • Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins, Journal of Immunological Methods, 2018 | Learn More
  • Discovery of stimulation-responsive immune enhancers with CRISPR activation, Nature, 2017 | Learn More
  • A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors, Nature Genetics, 2017 | Learn More
  • CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells, Scientific Reports, 2017 | Learn More
  • Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements, Nature Genetics, 2017 | Learn More
  • “T-bet”-ing on autoimmunity variants, PLOS Genetics, 2017 | Learn More

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells, Cell Reports, 2016 | Learn More

  • Genetic and epigenetic fine mapping of causal autoimmune disease variants, Nature, 2015 | Learn More
  • The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation, Immunity, 2015 | Learn More
  • Generation of knock-in primary human T cells using Cas9 ribonucleoproteins, PNAS, 2015 | Learn More
  • Genetic basis of autoimmunity, The Journal of Clinical Investigation, 2015 | Learn More
  • Small-molecule ROR-gamma-t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms, Immunity, 2014 | Learn More
  • Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells, Cell, 2008 | Learn More
  • Wnt signaling promotes reprogramming of somatic cells to pluripotency, Cell Stem Cell, 2008 | Learn More
  • Foxp3 occupancy and regulation of key target genes during T-cell stimulation, Nature, 2007 | Learn More

Featured In

News

Media highlights of Alex and the lab’s research.
Living Therapeutics Initiative Will Accelerate Development and Delivery of Revolutionary Treatments
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Gene Editing Expands to New Types of Immune Cells
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Gladstone Scientist Uses YouTube to Fight COVID-19 Misinformation in India
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How CRISPR Tools are Unlocking New Ways to Fight Disease
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Crispr: Breakthrough announced in technique of 'editing' DNA to fight off deadly illnesses
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CRISPR-Based “Discovery Engine” for New Cell Therapies to Advance Cancer Treatments
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With new genes and an electric shock, scientists turn immune cells against cancer
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Swift Gene-Editing Method May Revolutionize Treatments for Cancer and Infectious Diseases
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First Human Trial of Engineered T cells
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In autoimmune diseases affecting millions, researchers pinpoint genetic risks, cellular culprits
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Blunting CRISPR’s “scissors” gives new insight into autoimmune disorders
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"Gentler” CRISPR sheds light on autoimmune disease
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Engineering the Next Generation of Cell Therapies
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Once Science Fiction, Gene Editing is Now a Looming Reality
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Genetic Network that Differentiates Regulatory T Cells Mapped
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Scientists map genes controlling immune system “brakes”
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CRISPR identifies genes that might be targeted to hobble HIV infection
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Antibody Test, Seen as Key to Reopening Country, Does Not Yet Deliver
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Stellar Science Solving Cancer and COVID-19
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Meet Dr. Alexander Marson, One of CRI’s New Lloyd J. Old STARs
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The Immuno-Revolution: Resolving “Complexity Exemplified”
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Gladstone launches 2 new institutes — one focused on Covid-19, the other on cell therapies
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Two New Research Institutes in the Bay Area
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Why DNA is the Most Exciting Programming Language Today
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Coronavirus Antibody Tests: Can You Trust the Results?
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Interviews

Recent videos and interviews with Alex.
Bio Eats World: Discovery, Translation, and the State of Bio Today
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Alex appears on 60 minutes to discuss COVID-19 antibody testing
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Alex discusses the COVID testing project on CNN
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Science is Fun Podcast
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American Society of Gene & Cell Therapy (ASGCT) Meeting
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Stay Updated

Keep up-to-date with the latest research from the Marson lab.

So about that genomic immunology institute we've been building at @GladstoneInst @UCSF ... excited ... to say we now have faculty! We have labs! We have really cool research going on! Learn about all the cool stuff we're doing at our symposium on November 3: https://gladstone.org/events/gladstone-ucsf-institute-genomic-immunology-symposium-nov-3

Excited about our Genomic Immunology Institute symposium coming up Nov 3! Register to learn more ... about what we’ve been building and to hear about how we’re using genomic technologies to engineer immunotherapies and understand human immunity 👇

Come work with us 👇

Schedule An Interview

Contact Jackie Sawin to schedule an interview with Alex Marson.