Publications
Links to all papers from the lab are organized by year of publication.
- Efficient Generation of Isogenic Primary Human Myeloid Cells using CRISPR-Cas9 Ribonucleoproteins, Cell Reports
- XYZeq: Spatially resolved single-cell RNA sequencing reveals expression heterogeneity in the tumor microenvironment, Science Advances
- CRISPR activation and interference screens in primary human T cells decode cytokine regulation, bioRxiv
- Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks, bioRxiv
- Evaluation of SARS-CoV-2 serology assays reveals a range of test performance, Nature Biotechnology
- Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies, Cell
- Functional CRISPR dissection of gene networks controlling human regulatory T cell identity, Nature Immunology
- CRISPR screen in regulatory T cells reveals modulators of Foxp3, Nature
- Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency, Nature Biotechnology
- Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR), EMBO J
- Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair, Nature Communications
- T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk, bioRxiv
- Landscape of stimulation-responsive chromatin across diverse human immune cells, Nature Genetics, 2019 | Learn More
- Orthotopic replacement of T-cell receptor alpha and beta chains with preservation of near-physiological T-cell function, Nature Biomedical Engineering, 2019 | Learn More
- CRISPR-Based Tools in Immunity, Annual Review of Immunology, 2019 | Learn More
- Helios enhances the preferential differentiation of human fetal CD4+ naive T cells into regulatory T cells, Science Immunology, 2019 | Learn More
- A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells, Immunity, 2019 | Learn More
- Large dataset enables prediction of repair after CRISPR-Cas9 editing in primary T cells, Nature Biotechnology, 2019 | Learn More
- A large CRISPR-induced bystander mutation causes immune dysregulation, Communications Biology, 2019 | Learn More
- CRISPR-Cas9 genome engineering of primary CD4 + T cells for the interrogation of HIV-host factor interactions, Nature Protocols, 2019 | Learn More
- Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function, Cell, 2018 | Learn More
- Reprogramming human T cell function and specificity with non-viral genome targeting, Nature, 2018 | Learn More
- CRISPR-Cas9 genome engineering of primary CD4 + T cells for the interrogation of HIV-host factor interactions, Nature Protocols, 2018 | Learn More
- Multiplexed droplet single-cell RNA-sequencing using natural genetic variation, Nature Biotechnology, 2018 | Learn More
- Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins, Journal of Immunological Methods, 2018 | Learn More
- Discovery of stimulation-responsive immune enhancers with CRISPR activation, Nature, 2017 | Learn More
- A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors, Nature Genetics, 2017 | Learn More
- CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells, Scientific Reports, 2017 | Learn More
- Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements, Nature Genetics, 2017 | Learn More
- “T-bet”-ing on autoimmunity variants, PLOS Genetics, 2017 | Learn More
A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells, Cell Reports, 2016 | Learn More
- Genetic and epigenetic fine mapping of causal autoimmune disease variants, Nature, 2015 | Learn More
- The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation, Immunity, 2015 | Learn More
- Generation of knock-in primary human T cells using Cas9 ribonucleoproteins, PNAS, 2015 | Learn More
- Genetic basis of autoimmunity, The Journal of Clinical Investigation, 2015 | Learn More
- Small-molecule ROR-gamma-t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms, Immunity, 2014 | Learn More
- Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells, Cell, 2008 | Learn More
- Wnt signaling promotes reprogramming of somatic cells to pluripotency, Cell Stem Cell, 2008 | Learn More
- Foxp3 occupancy and regulation of key target genes during T-cell stimulation, Nature, 2007 | Learn More
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Friend & co-founder @nickhaining joins @ArsenalBio leadership!
"The sketch on the back of a ... cocktail napkin we drew w/ @EJohnWherry @MarsonLab @KoleRoybal @BradEBernstein et al is now a full-stack company ready to program the fate and function of T cells to cure cancer" -Nick
"CAR Pooling" accelerates design of CAR T cells. Pooled screens and single cell analysis reveal ... novel receptors that we hope will improve treatments. Amazing collaborative effort led by @dbgoodman and @CamilliaAzimi with @kickassscience1 and ArsenalBio co-founder @KoleRoybal.
At the Gladstone-UCSF Institute of Genomic Immunology, we're proud to be working toward a future ... #Immune2Cancer! @CancerResearch
#wearwhite #Immunotherapy @GladstoneInst @UCSFMedicine @parkerici
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