Publications

Links to all papers from the lab are organized by year of publication.

  • Evaluation of SARS-CoV-2 serology assays reveals a range of test performance, Nature Biotechnology, 2020 | Learn More
  • Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies, Cell, 2020 | Learn More
  • Functional CRISPR dissection of gene networks controlling human regulatory T cell identity, Nature Immunology, 2020 | Learn More
  • CRISPR screen in regulatory T cells reveals modulators of Foxp3, Nature, 2020 | Learn More
  • Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency, Nature Biotechnology, 2020 | Learn More
  • Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR), EMBO J, 2020 | Learn More
  • Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair, Nature Communications, 2020 | Learn More
  • T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk, bioRxiv, 2020 | Learn More
  • Efficient Generation of Isogenic Primary Human Myeloid Cells using CRISPR-Cas9 Ribonucleoproteins, bioRxiv, 2020 | Learn More
  • Landscape of stimulation-responsive chromatin across diverse human immune cells, Nature Genetics, 2019 | Learn More
  • Orthotopic replacement of T-cell receptor alpha and beta chains with preservation of near-physiological T-cell function, Nature Biomedical Engineering, 2019 | Learn More
  • CRISPR-Based Tools in Immunity, Annual Review of Immunology, 2019 | Learn More
  • Helios enhances the preferential differentiation of human fetal CD4+ naive T cells into regulatory T cells, Science Immunology, 2019 | Learn More
  • A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells, Immunity, 2019 | Learn More
  • Large dataset enables prediction of repair after CRISPR-Cas9 editing in primary T cells, Nature Biotechnology, 2019 | Learn More
  • A large CRISPR-induced bystander mutation causes immune dysregulation, Communications Biology, 2019 | Learn More
  • CRISPR-Cas9 genome engineering of primary CD4 + T cells for the interrogation of HIV-host factor interactions, Nature Protocols, 2019 | Learn More
  • Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function, Cell, 2018 | Learn More
  • Reprogramming human T cell function and specificity with non-viral genome targeting, Nature, 2018 | Learn More
  • CRISPR-Cas9 genome engineering of primary CD4 + T cells for the interrogation of HIV-host factor interactions, Nature Protocols, 2018 | Learn More
  • Multiplexed droplet single-cell RNA-sequencing using natural genetic variation, Nature Biotechnology, 2018 | Learn More
  • Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins, Journal of Immunological Methods, 2018 | Learn More
  • Discovery of stimulation-responsive immune enhancers with CRISPR activation, Nature, 2017 | Learn More
  • A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors, Nature Genetics, 2017 | Learn More
  • CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells, Scientific Reports, 2017 | Learn More
  • Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements, Nature Genetics, 2017 | Learn More
  • “T-bet”-ing on autoimmunity variants, PLOS Genetics, 2017 | Learn More

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells, Cell Reports, 2016 | Learn More

  • Genetic and epigenetic fine mapping of causal autoimmune disease variants, Nature, 2015 | Learn More
  • The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation, Immunity, 2015 | Learn More
  • Generation of knock-in primary human T cells using Cas9 ribonucleoproteins, PNAS, 2015 | Learn More
  • Genetic basis of autoimmunity, The Journal of Clinical Investigation, 2015 | Learn More
  • Small-molecule ROR-gamma-t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms, Immunity, 2014 | Learn More
  • Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells, Cell, 2008 | Learn More
  • Wnt signaling promotes reprogramming of somatic cells to pluripotency, Cell Stem Cell, 2008 | Learn More
  • Foxp3 occupancy and regulation of key target genes during T-cell stimulation, Nature, 2007 | Learn More

Featured In

News

Media highlights of Alex and the lab’s research.
How CRISPR Tools are Unlocking New Ways to Fight Disease
Read More >>
Crispr: Breakthrough announced in technique of 'editing' DNA to fight off deadly illnesses
Read More >>
CRISPR-Based “Discovery Engine” for New Cell Therapies to Advance Cancer Treatments
Read More >>
With new genes and an electric shock, scientists turn immune cells against cancer
Read More >>
Swift Gene-Editing Method May Revolutionize Treatments for Cancer and Infectious Diseases
Read More >>
First Human Trial of Engineered T cells
Read More >>
In autoimmune diseases affecting millions, researchers pinpoint genetic risks, cellular culprits
Read More >>
Blunting CRISPR’s “scissors” gives new insight into autoimmune disorders
Read More >>
"Gentler” CRISPR sheds light on autoimmune disease
Read More >>
Engineering the Next Generation of Cell Therapies
Read More >>
Once Science Fiction, Gene Editing is Now a Looming Reality
Read More >>
Genetic Network that Differentiates Regulatory T Cells Mapped
Read More >>
Scientists map genes controlling immune system “brakes”
Read More >>
CRISPR identifies genes that might be targeted to hobble HIV infection
Read More >>
Antibody Test, Seen as Key to Reopening Country, Does Not Yet Deliver
Read More >>
Stellar Science Solving Cancer and COVID-19
Read More >>
Meet Dr. Alexander Marson, One of CRI’s New Lloyd J. Old STARs
Read More >>
The Immuno-Revolution: Resolving “Complexity Exemplified”
Read More >>
Gladstone launches 2 new institutes — one focused on Covid-19, the other on cell therapies
Read More >>
Two New Research Institutes in the Bay Area
Read More >>
Why DNA is the Most Exciting Programming Language Today
Read More >>
Coronavirus Antibody Tests: Can You Trust the Results?
Read More >>

Interviews

Recent videos and interviews with Alex.
Alex appears on 60 minutes to discuss COVID-19 antibody testing
View Now >>
Alex discusses the COVID testing project on CNN
View Now >>
Science is Fun Podcast
View Now >>
American Society of Gene & Cell Therapy (ASGCT) Meeting
View Now >>

Stay Updated

Keep up-to-date with the latest research from the Marson lab.

Congrats to newly minted Dr. Joe Hiatt! Joe has already has made major contributions to ... understanding host-pathogen interactions, including shedding light on COVID-19. Over 100 friends, family, and fans showed up virtually for awesome talk. @GladstoneInst @immunox

Congrats to @MarsonLab postdoc Zach Steinhart on his Parker Scholar award! @parkerici @GladstoneInst... @UCSF @UCSFMedicine https://twitter.com/parkerici/status/1367120289658765315

Check out our updated lab website: https://marsonlab.org/

Goodbye to the version I made when I ... taught myself Drupal before starting the lab in 2013. This does better justice to the scientific momentum of current lab members and collaborators. @GladstoneInst @ucsf @immunox

Schedule An Interview

Contact Jackie Sawin to schedule an interview with Alex Marson.