CRISPR activation and interference screens decode stimulation responses in primary human T cells

Gene Editing Expands to New Types of Immune Cells

Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins

Genetic Network that Differentiates Regulatory T Cells Mapped

Scientists map genes controlling immune system “brakes”

Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies

Functional CRISPR dissection of gene networks controlling human regulatory T cell identity

CRISPR screen in regulatory T cells reveals modulators of Foxp3

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

Functional Genomics Of Immune Cells

Human T cells are critical effectors of the immune response as well as autoimmune disease and are attractive tools for cancer immunotherapy. The lab has developed CRISPR-based methods for functional genomic screens identifying genes and networks crucial to the development, fate, and function of human T cells, as well as extending these efforts to other […]