Obesity alters pathology and treatment response in inflammatory disease

How Obesity Can Rewire the Immune System and the Response to Immunotherapy—and How to Change That

Obesity can turn a helpful immunotherapy into a harmful one, mouse study shows

In autoimmune diseases affecting millions, researchers pinpoint genetic risks, cellular culprits

Blunting CRISPR’s “scissors” gives new insight into autoimmune disorders

“Gentler” CRISPR sheds light on autoimmune disease

T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk

Landscape of stimulation-responsive chromatin across diverse human immune cells

Genetics and Epigenomics of Immune Function and Autoimmune Disease

We are working toward understanding the genetic circuits that control human immune cell function in health and disease, including exploring the genetic basis of immune-mediated diseases, both monogenic and complex. We participate in collaborative research aimed at broadly understanding chromatin and gene expression regulation of human primary immune cells, allowing downstream annotation of candidate causal […]

Discovery of stimulation-responsive immune enhancers with CRISPR activation