Obesity alters pathology and treatment response in inflammatory disease
How Obesity Can Rewire the Immune System and the Response to Immunotherapy—and How to Change That
Obesity can turn a helpful immunotherapy into a harmful one, mouse study shows
In autoimmune diseases affecting millions, researchers pinpoint genetic risks, cellular culprits
Blunting CRISPR’s “scissors” gives new insight into autoimmune disorders
“Gentler” CRISPR sheds light on autoimmune disease
T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk
Landscape of stimulation-responsive chromatin across diverse human immune cells
Genetics and Epigenomics of Immune Function and Autoimmune Disease
We are working toward understanding the genetic circuits that control human immune cell function in health and disease, including exploring the genetic basis of immune-mediated diseases, both monogenic and complex. We participate in collaborative research aimed at broadly understanding chromatin and gene expression regulation of human primary immune cells, allowing downstream annotation of candidate causal […]