Genetic Network that Differentiates Regulatory T Cells Mapped

Scientists map genes controlling immune system “brakes”

Functional CRISPR dissection of gene networks controlling human regulatory T cell identity

CRISPR screen in regulatory T cells reveals modulators of Foxp3

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells

Regulatory T Cell Function And Therapeutics

Regulatory T cells are critical for protection against autoimmune and inflammatory diseases and are under development at UCSF as cellular therapies to treat a wide range of diseases. The genetic underpinnings of Treg identity have been a long-standing area of focus for our work. Recently, the lab has made significant strides to discover genes critical […]

Foxp3 occupancy and regulation of key target genes during T-cell stimulation