Our Research
We are passionate about merging technology with medicine and expediting discovery at the cutting edge of genomic immunology.
What We Do
Human T cells are critical effectors of immunity, autoimmune pathology and cancer immunotherapy. Functional genetic studies in human T cells could reveal pathways that control cell function, prioritize targets for drug development, and improve the design of genetically reprogrammed cell-based therapies. By developing and applying platforms for CRISPR-Cas9 manipulation and screening in primary human T cells, we explore protein-coding and non-coding genetic mechanisms that regulate T cell functions and work toward therapeutic engineering of cells to treat cancer, HIV, primary immune deficiencies, and autoimmune diseases.
Investigation of the genome-wide regulation of human immunity and its dysregulation in autoimmune pathologies.
Development and application of CRISPR-based genome editing methods to screen for genes impacting immune cell fate and function, with a particular focus on T cells.
Targeted investigation of the gene programs underlying regulatory T cell suppressive functions and mechanisms to modulate T cell fate.
Development and application of CRISPR-based genome editing methods to screen for genes impacting immune cell fate and function, with a particular focus on T cells.
Investigation of the genome-wide regulation of human immunity and its dysregulation in autoimmune pathologies.
Support Marson Lab
Our research is made possible by a combination of grants and philanthropic gifts. If you are excited about the work we are doing and are interested in contributing, please get in touch.
