Our Research

We are passionate about merging technology with medicine and expediting discovery at the cutting edge of genomic immunology.

What We Do

Human T cells are critical effectors of immunity, autoimmune pathology and cancer immunotherapy. Functional genetic studies in human T cells could reveal pathways that control cell function, prioritize targets for drug development, and improve the design of genetically reprogrammed cell-based therapies. By developing and applying platforms for CRISPR-Cas9 manipulation and screening in primary human T cells, we explore protein-coding and non-coding genetic mechanisms that regulate T cell functions and work toward therapeutic engineering of cells to treat cancer, HIV, primary immune deficiencies, and autoimmune diseases.

Investigation of the genome-wide regulation of human immunity and its dysregulation in autoimmune pathologies.
Development and application of CRISPR-based genome editing methods to screen for genes impacting immune cell fate and function, with a particular focus on T cells.
Targeted investigation of the gene programs underlying regulatory T cell suppressive functions and mechanisms to modulate T cell fate.
Development and application of CRISPR-based genome editing methods to screen for genes impacting immune cell fate and function, with a particular focus on T cells.
Investigation of the genome-wide regulation of human immunity and its dysregulation in autoimmune pathologies.

Support Marson Lab

Our research is made possible by a combination of grants and philanthropic gifts. If you are excited about the work we are doing and are interested in contributing, please get in touch.

Our People

The Marson lab includes a diverse group of trainees and research technicians with expertise in genomics, immunology, infectious disease, and CRISPR technologies, among other topics. Detailed bios for each lab member can be found on our People page.