Our Research
The goal of our lab is to understand genetic circuits that control human immune cell function in health and disease, employing powerful new CRISPR genome engineering technologies. We are focused on elucidating the genetic and epigenetic regulation of human immune cells and the development and application of gene editing technologies to manipulate immune cells to fight diseases including cancer, autoimmunity, and infectious disease. The lab is decoding gene programs in pro-inflammatory T cells that drive effective anti-cancer immune responses and programs in anti-inflammatory regulatory T cells (Tregs) that are critical to prevent autoimmunity. Using tools developed in the lab for CRISPR genome engineering in primary human T cells we are pursuing a comprehensive strategy to test how coding and non-coding genetic variation controls functional programs in the immune system and extending our genome engineering capabilities to reprogram the next generation of cellular therapies.
Our Partners
Our People
The Marson lab is a team of highly collaborative students, research technicians, and postdoctoral scientists with expertise across the fields of genomics, immunology, infectious diseases and genome engineering.
In the News
Media highlights of Alex and the lab’s research.
Stay Updated
Keep up-to-date with the latest research from the Marson lab.
“T-cells are a central cell type that we can engage in a number of different ways to start ...orchestrating responses to treat cancer.” — @MarsonLab https://arkinv.st/3T1F4ao
Looking forward to this for a number of reasons, including the opportunity to catch up with my PhD ...Mentor @youngricka. Should be a great meeting!
Now Live! – “From Bench to Fireside,” a conversation between John Connolly, PhD, and Alex ...Marson, MD, PhD, @MarsonLab at Gladstone-@UCSF Institute of Genomic Immunology, and, now, director of PICI @GladstoneInst. https://youtu.be/VA7bKIQ7cA4 #PICINetwork
Recent Lab News
March 2021
Ujjwal Rathore was awarded the Mathilde Krim fellowship by The Foundation for AIDS Research (amfAR).
November 2020
Tori Yamamoto has been appointed a Zena Werb scholar as a T32 trainee.
June 2020
Alex is featured on 60 minutes to discuss COVID-19 antibody testing.
March 2021
Zach Steinhart was selected for the Parker Scholar award from the Parker Institute for Cancer Immunotherapy.
August 2020
The Marson lab has moved into space at the new Gladstone-UCSF Institute of Genomic Immunology.
May 2020
Alex is named Director of the newly launching Gladstone-UCSF Institute of Genomic Immunology.