Our Research
We are passionate about merging technology with medicine and expediting discovery at the cutting edge of genomic immunology.
Human T cells drive protection from infection, are central actors in cancer immunotherapy, and drive much of the pathology associated with autoimmune disease. Functional genetic studies in human T cells could reveal pathways that control cell function, prioritize targets for drug development, and improve the design of genetically reprogrammed cell-based therapies.
By developing and applying platforms for CRISPR-Cas9 manipulation and screening in primary human T cells, we explore protein-coding and non-coding genetic mechanisms that regulate T cell functions and work toward therapeutic engineering of cells to treat cancer, HIV, primary immune deficiencies, and autoimmune diseases.
Genetics and Epigenomics of Immune Function and Autoimmune Disease
Investigation of the genome-wide regulation of human immunity and its dysregulation in autoimmune pathologies.
Functional Genomics of Immune Cells
Development and application of CRISPR-based genome editing methods to screen for genes impacting immune cell fate and function, with a particular focus on T cells.
Regulatory T Cell Function And Therapeutics
Targeted investigation of the gene programs underlying regulatory T cell suppressive functions and mechanisms to modulate T cell fate.
Engineering Immune Cells For Therapeutic Benefit
Development and application of CRISPR-based genome editing methods to screen for genes impacting immune cell fate and function, with a particular focus on T cells.
Genetics Of The Host-Pathogen Interface
Investigation of the genome-wide regulation of human immunity and its dysregulation in autoimmune pathologies.
Support Marson Lab
Our research is made possible by a combination of grants and philanthropic gifts. If you are excited about the work we are doing and are interested in contributing, please get in touch.
